Search Labs

Yu Lab is interested in the molecular and cellular basis of Alzheimer’s disease, amyotrophic lateral sclerosis, frontotemporal dementia, and related neurodegenerative disorders.

The Yu lab focuses on anisosomes, TDP-43 aggregation, and molecular glue in studying the mechanisms behind age-related neurodegeneration.

The Yue lab studies molecular and cellular mechanisms underlying musculoskeletal regeneration and tumorigenesis, and develops novel immunotherapeutics to treat patients.

Zaki Lab's research focuses on the the study of gastrointestinal inflammation and cancer.

Zaman’s Lab focuses on the design and development of novel cutting-edge multi-mode imaging systems to overcome current limitations in clinical systems. Most recent research project is involved with the design and developed of a multimode catheter-based imaging system called a Circumferential Intravascular Radioluminescence Photoacoustic Imaging (CIRPI) for early detection of thin-cap-fibro-atheroma (TCFA), the underlying causes of coronary artery disease, one of the leading causes of morbidity and mortality in the USA and worldwide. Further, the CIRPI system characterizes the plaques based on disease tissue compositions to unravel their complex structures. This CIRPI system integrates optical, photoacoustic, radioluminescence and ultrasound imaging. We seek to better understand the underlying causes of the disease mechanisms. We are dissecting the role of TCFA perturbations on vascular wall processes during atherosclerosis progression. Our lab also studying novel molecular imaging methods to study coronary arterial disease, carotid stenosis, and myocardial ischemia in subcellular level.

Zang Lab investigates the molecular mechanisms underlying the pathogenesis of sepsis. We use the heart as a model, since cardiac dysfunction is a vital component of multi-organ failure during sepsis.

Zeng Lab is interested in understanding at the molecular level key questions lying at the interface between biochemistry, cell biology, metabolic and neural physiology, including the bidirectional communication between autonomic neurons and adipocytes, the molecular basis of the phenotypic plasticity, or the lack of, in brown, beige and white adipocytes, and roles of uncharacterized enzymatic pathways in adipose thermogenesis.

Zhan Lab's mission is to advance medical genetics research through cutting-edge statistic models and computationally efficient software tools

The lab's long-term goal is to illuminate the function of immune surface molecules and to open up a new research field at the interface of cancer, immunology, and stem cell research. Zhang Lab also actively develops novel therapies for cancer treatment.

Zhang (Chun-Li) Lab research focuses on cellular plasticity in the adult nervous system and modeling human neurodegenerative diseases. We use cell culture and genetically modified mice as model systems. Molecular, cellular, electrophysiological, and behavioral methods are employed.

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Our lab currently studies hypoxia, prolyl hydroxylase, and VHL signaling in cancer, especially breast and renal cell carcinomas.

The central theme of our research program in our laboratory is to explore the co-evolution between tumor cells and the tumor microenvironment (TME) during the development of therapeutic resistance and metastatic relapse.

Our lab combines normative theories and biologically plausible neural circuit models to study the principles of neural information processing, in order to answer how perception, cognition, and behavior emerge from neural circuits. 

The Zhang lab studies intra- and inter-molecular interactions to understand how signaling proteins are regulated, using biochemistry, X-ray crystallography, cryo-EM and cell biology.

In the Zhang Lab, we seek to understand the molecular mechanisms of metabolic diseases, with the long-term goal of creating novel therapeutic strategies.

Zheng Lab is dedicated to women’s health care, specializing in gynecologic pathology, particularly in oncologic and hormone related pathology within the GYN Pathology field.

Zhong Lab studies studies inflammation, mitochondrial stress responses, tumor immunology and obesity-associated liver disorders.  

Our aim is to develop computational methods to unveil the hidden biological circuitries behind the data, from understanding sequence-based regulations to the evolution of genomes and their impact to diseases.

Our lab is interested in understanding the relationship between injury, regeneration, and cancer. We are focused on identifying the genes and mechanisms that regulate regenerative capacity in the liver and understanding how these contribute to hepatocellular carcinoma development.

The Zia Research Group focuses on clinical and translational hematology research to improve the understanding of pediatric thrombotic and hemostatic disorders with the long-term goal of improving the lives of affected children and young adults with these disorders.

We investigate the neuro-hormonal basis for complex eating behaviors and blood glucose control, with the ultimate goal of designing new methods to prevent and treat extremes of body weight, blood glucose, and associated disorders of mood and metabolism.