While cardiac and thoracic surgeries are often life-saving and may invoke life-changing improvements in health related quality of life, many patients also experience varying degrees of end organ injury and associated complications that can persist in the years following surgery. In 2014 Amanda Fox, M.D., M.P.H. initiated a genomics, biomarkers and outcomes research group at UTSW. This group values multi-specialty collaborations between anesthesiologists, surgeons cardiologists, radiologists, critical care physicians, biostatisticians, geneticists, bench scientists, and many other specialties.
Obesity and metabolic diseases have been increasing at the alarming rate and threatening our health and economy over the world. However, we still don’t know much about how our metabolic homeostasis is regulated. Understanding the mechanism underlying the regulation of metabolism is a fundamental step towards designing new treatments for obesity and its associated diseases, and many other metabolic diseases
Our research is driven by a desire to understand how these microscopic machines both replicate themselves and, at the same time, manage to evade, manipulate, and counter a myriad of host defenses.
The autonomic nervous system comprises a network of sensory and motor neurons that connect the brainstem and spinal cord to thoracic and abdominal organs. A better understanding of the anatomical and functional plasticity of the autonomic nervous system will likely move forward our understanding of numerous chronic diseases including, but not limited to, obesity, diabetes, visceral pain, neuropathy, and eating disorders.
Dr. Gibson's current research focuses on the changes in neocortical circuitry in the mouse model of Fragile X Syndrome (the Fmr1 KO mouse), and the mechanisms underlying these changes.
The Glass lab focuses on how genes regulate skin development and function by studying how gene mutations or abnormal gene expression lead to skin disease.
The Gloeggler lab is interested in spin phenomena and explores how to use them as new contrast mechanism for magnetic resonance. One focus is on using parahydrogen, a spin isomer of hydrogen gas, and how to harvest its spin order to obtain signal enhanced/hyperpolarized contrast agents.
The Gospocic group studies how epigenetic pathways and gene expression regulate brain plasticity in the context of social behavior and aging by working with a unique ant species Harpegnathos saltator. We take a multidisciplinary approach and combine functional genomics, biochemistry, and behavioral assays in H. saltator, as well as the conventional Drosophila and mouse models to expedite genetic screening and provide evolutionary context to identified epigenetic pathways.
The Goss lab collaborates with a multidisciplinary group of researchers to study the heart and lungs long after preterm birth. We are part of the Parkland Outcomes after Prematurity Study (POPS), which conducts collaborative research on outcomes of prematurity from birth through adulthood.
The general focus of the Green Lab is to understand the molecular mechanism of the mammalian circadian clock, how it controls rhythmic biochemistry, physiology and behavior and how loss of clock function can impact health, resulting in metabolic disease, cancer and other ailments.
The Greenberg lab is focused on the development of novel therapeutic approaches to combat infectious diseases. For specific projects, please click on the links to the left.
Our lab uses a combination of electrophysiological and molecular techniques to examine functions sub-served by these states at the cellular and circuit levels.
Working at the boundary between science and philosophy with the goal to inform public policy and advance science education and public understanding of science.
